A common cause of micropenis is congenital hypogonadotropic hypogonadism, whether
isolated or associated with multiple pituitary hormone deficiencies. The postnatal surge in …

Origin of the adrenogonadal primordium The adrenal glands develop from 2 separate
embryologic tissues: the medulla is derived from neural crest cells originating in proximity to …

Since its discovery in the early 1990s, the orphan nuclear receptor SF-1 has been attributed
a central role in the development and differentiation of steroidogenic tissues. SF-1 controls …

Male sexual differentiation of the brain and behavior are thought, on the basis of
experiments in rodents, to be caused by androgens, following conversion to estrogens …

Steroidogenic factor 1 (SF-1, also called Ad4BP and NR5A1) is a nuclear receptor with
critical roles in steroidogenic tissues, as well as in the brain and pituitary. In particular, SF-1 …

The orphan nuclear receptors SF-1 and LRH-1 are constitutively active, but it remains
uncertain whether their activation is hormone dependent. We report the crystal structure of …

Ovarian development is a complex process controlled by precise coordination of multiple
factors. The targeted gene knockout technique is a powerful tool to study the functions of …

The adrenal cortex is divided into concentric zones. In humans the major cortical zones are
the zona glomerulosa, zona fasciculata, and zona reticularis. The adrenal cortex is a …

The embryonic gonad is undifferentiated in males and females until a critical stage when the
sex chromosomes dictate its development as a testis or ovary. This binary developmental …

Steroidogenic factor-1 (SF-1) and liver receptor homologue-1 (LRH-1) belong to the fushi
tarazu factor 1 subfamily of nuclear receptors. SF-1 is an essential factor for sex …