Neuroblastoma (NB), the most common extracranial solid tumor in childhood, is an
extremely heterogeneous disease both biologically and clinically. Although significant …

Clinically, we apply synthetic glucocorticoids to treat fetal and maternal diseases, such as
premature labor and autoimmune diseases. Although its clinical efficacy is positive, the fetus …

We and others have previously demonstrated that retinal cells can be derived from human
embryonic stem cells (hESCs) and induced pluripotent stem cells under defined culture …

Human germ cell tumors are of interest because of their epidemiology, clinic and
pathobiology. Histologically, they are subdivided into various elements, with similarities to …

Abstract Development of the retina is regulated by growth factors, such as insulin-like growth
factors 1 and 2 (IGF-1/2), which coordinate proliferation, differentiation, and maturation of the …

Aim Neuroblastoma is a heterogeneous childhood cancer derived from the neural crest. The
dual cell identities of neuroblastoma include Mesenchymal (MES) and Adrenergic (ADRN) …

Pituitary growth hormone (GH) and insulinlike growth factor (IGF)-1 are anabolic hormones
whose physiological roles are particularly important during development. The activity of the …

In somatic cell reprogramming, cells must escape the somatic cell-specific gene expression
program to adopt other cell fates. Here, in vitro chemical induction with RepSox generated …

Blindness represents an increasing global problem with significant social and economic
impact upon affected patients and society as a whole. In Europe, approximately one in 30 …

AIM To explore the susceptible association between the insulin-like growth factor-1 receptor
(IGF1R) single nucleotide polymorphism (SNP) and age-related cataract (ARC), and …