Metabolic glycoengineering with unnatural sugars provides a powerful tool to label cell
membranes with chemical tags for subsequent targeted conjugation of molecular cargos via …

In metabolic glycoengineering (MGE), cells or animals are treated with unnatural derivatives
of monosaccharides. After entering the cytosol, these sugar analogues are metabolized and …

Metabolic chemical reporters (MCRs) of glycosylation are analogues of monosaccharides
that contain bioorthogonal functionalities and enable the direct visualization and …

Cell‐surface sialic acids are essential in mediating a variety of physiological and
pathological processes. Sialic acid chemistry and biology remain challenging to investigate …

Protein glycosylation events that happen early in the secretory pathway are often
dysregulated during tumorigenesis. These events can be probed, in principle, by …

Highlights•Popular bioorthogonal reagents and reactions are highlighted.•Methods to tune
bioorthogonal functional group reactivity and stability are described.•Strategies to achieve …

We herein report a chemical decaging strategy for the in situ generation of neuramic acid
(Neu), a unique type of sialic acid, on live cells by the use of a palladium‐mediated …

Glycosylation events play an invaluable role in regulating cellular processes including
enzymatic activity, immune recognition, protein stability, and cell–cell interactions. However …

Metabolic oligosaccharide engineering is a valuable tool to monitor cellular carbohydrates.
Here, we report the synthesis of a novel N-acyl-mannosamine derivative bearing a …

Sialic acids cap the glycans of cell surface glycoproteins and glycolipids. They are involved
in a multitude of biological processes and aberrant sialic acid expression is associated with …