Abstract Type 2 diabetes (T2DM) results when increases in beta cell function and/or mass
cannot compensate for rising insulin resistance. Numerous studies have documented the …

Pancreatic β-cells possess an inherent ability to generate oscillatory signals that trigger
insulin release. Coordination of the secretory activity among β-cells results in pulsatile …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

Impairment of insulin secretion from the β-cells of the pancreatic islets of Langerhans is
central to the development of type 2 diabetes mellitus and has therefore been the subject of …

The pancreatic β-cell secretes insulin in response to elevated plasma glucose. This review
applies an external bioenergetic critique to the central processes of glucose-stimulated …

In islets of Langerhans, oxidative stress induced by reactive oxygen species (ROS) is
thought to be critically involved in β-cell dysfunction during the development of diabetes …

Hormone rhythms are ubiquitous and essential to sustain normal physiological functions.
Combined mathematical modelling and experimental approaches have shown that these …

Insulin secretion from pancreatic islet β-cells occurs in a pulsatile fashion, with a typical
period of∼ 5 min. The basis of this pulsatility in mouse islets has been investigated for more …

Islets of Langerhans are multicellular microorgans located in the pancreas that play a central
role in whole-body energy homeostasis. Through secretion of insulin and other hormones …

Adenosine 5′-triphosphate is a universal molecule in all living cells, where it functions in
bioenergetics and cell signaling. To understand how the concentration of ATP is regulated …