Metastatic melanoma is notoriously one of the most difficult cancers to treat. Although many
therapeutic regimens have been tested, very few achieve response rates greater than 25 …

Abstract Since the mid-1950's, melanoma incidence has been rising steadily in
industrialized Caucasian populations, thereby pointing to the pivotal involvement of …

Malignant melanoma is an aggressive tumor of the skin with a poor prognosis for patients
with advanced disease. It is resistant to current therapeutic approaches. In melanoma, both …

Tumour budding or dedifferentiation at the invasive margin of colorectal cancer (CRC) is an
important prognostic marker and linked mechanistically to dysregulation of Wnt pathway …

Simple Summary Melanoma is a dreadful type of skin cancer with a poor response to
therapy. Senescent cells have been found to accumulate with age and may contribute to the …

Malignant melanoma remains one of the most deadly human cancers with no effective cures
for metastatic disease. The poor efficacy of current therapy in advanced melanoma …

MicroRNAs are a class of small non-coding, endogenous RNAs involved in cancer
development and progression. MicroRNA-221 (mir-221) has been reported to have both an …

Irreversible changes in the DNA sequence, including chromosomal deletions or
amplification, activating or inactivating mutations in genes, have been implicated in the …

Deregulation of apoptosis is associated with various pathologies, such as
neurodegenerative disorders at one end of the spectrum and cancer at the other end …

Melanoma is the most aggressive form of skin cancer and advantages stages are inevitably
resistant to conventional therapeutic agents. In particular, the inability of undergo apoptosis …