Gastric cancer is diagnosed in nearly one million new patients each year and it remains the
second leading cause of cancer-related deaths worldwide. Although gastric cancer …

Although the estimated time for development of pancreatic ductal adenocarcinoma (PDA) is
more than 20 years, PDAs are usually detected at late, metastatic stages. PDAs develop …

Pyroptosis is a proinflammatory mode of lytic cell death mediated by accumulation of plasma
membrane (PM) macropores composed of gasdermin‐family (GSDM) proteins. It facilitates …

Multiple sclerosis (MS), and its animal model experimental autoimmune encephalomyelitis,
are neuroinflammatory diseases driven by autoreactive pathogenic TH cells that elicit …

Mast cells (MCs) are best-known as key effector cells of immediate-type allergic reactions
that may even culminate in life-threatening anaphylactic shock syndromes. However …

Although mast cells (MCs) are known as key drivers of type I allergic reactions, there is
increasing evidence for their critical role in host defense. MCs not only play an important role …

Psoriasis is a chronic inflammatory immune skin disease mediated by genetic and
environmental factors. As a bridge between innate and adaptive immunity, mast cells are …

Objectives Mast cells (MCs) are involved in the pathogenesis of rheumatoid arthritis (RA).
However, their contribution remains controversial. To establish their role in RA, we analysed …

When related to central nervous system (CNS) health and disease, brain mast cells (MCs)
can be a source of either beneficial or deleterious signals acting on neural cells. We review …

Mast cells secrete a wide spectrum of stored or newly synthesized pro-inflammatory, anti-
inflammatory, and/or immunosuppressive mediators and express several costimulatory and …