The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

Humans are highly susceptible to infection with respiratory viruses including respiratory
syncytial virus (RSV), influenza virus, human metapneumovirus, rhinovirus, coronavirus, and …

Respiratory syncytial virus (RSV) is amongst the most important pathogenic infections of
childhood and is associated with significant morbidity and mortality. Although there have …

In animal models, resident memory CD8+ T (Trm) cells assist in respiratory virus elimination
but their importance in man has not been determined. Here, using experimental human …

INTRODUCTION Even with intimate exposure to a virus, some people fail to become
infected. Variable transmission partly depends on the dose and duration of exposure but is …

To investigate whether the inflammatory process in peripheral airways is different in smokers
who develop symptoms of chronic bronchitis and chronic airflow limitation and in …

Respiratory syncytial virus (RSV) infection has an estimated global incidence of 33 million
cases in children younger than 5 years, with 10% requiring hospital admission and up to …

Respiratory syncytial virus (RSV) is an exceptional mucosal pathogen. It specializes in
infection of the ciliated respiratory epithelium, causing disease of variable severity with little …

Mechanisms of immune suppression in peripheral tissues counteract protective immunity to
prevent immunopathology and are coopted by tumors for immune evasion. While lymphatic …

Respiratory Syncytial Virus (RSV) is the commonest cause of severe respiratory infection in
infants, leading to over 3 million hospitalizations and around 66,000 deaths worldwide each …