5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Background: The aim of this review was to identify the mechanisms by which serotonin
receptors involved at the central level are able to modulate the nociceptive response. Pain is …

HT plays a crucial role in the progress and adjustment of pain both centrally and
peripherally. The therapeutic action of the 5-HT receptorsagonist and antagonist in …

Abstract Among monoamine neurotransmitters, serotonin (5-HT) is known to play complex
modulatory roles in pain signaling mechanisms since the first reports, about forty years ago …

Chronic neuropathic pain is a debilitating ordeal for patients worldwide and
pharmacological treatment efficacy is still limited. As many pharmacological interventions for …

Chronic primary pain (CPP) is a group of diseases with long‐term pain and functional
disorders but without structural or specific tissue pathologies. CPP is becoming a serious …

Monoamines are involved in regulating the endogenous pain system and indeed, peripheral
and central monoaminergic dysfunction has been demonstrated in certain types of pain …

Simple Summary Fiber pathways that descend from the brain to the spinal cord drive motor
behavior and modulate incoming sensory signals and the capacity to change (plasticity). A …

Background: Despite the extensive number of studies performed in the last 50 years, aimed
at describing the role of serotonin and its receptors in pain modulation at the spinal cord …

Abstract Ethnopharmacological relevance Croton urucurana (Euphorbiaceae) is popularly
used in Brazil to treat inflammatory processes, pain, and gastric ulcers. Aim of study To …