The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …

Abstract CD4+ regulatory T cells (T regs) expressing the transcription factor FoxP3 are
highly immune suppressive and play central roles in the maintenance of self-tolerance and …

Single agent checkpoint inhibitor therapy has not been effective for most gastrointestinal
solid tumors, but combination therapy with drugs targeting additional immunosuppressive …

T cells in tumors—the so-called tumor infiltrating lymphocytes (TIL) have been studied
intensively over the past years. Compelling evidence point to a clinical relevance for high …

At the present time, regulatory T cells (Tregs) are an integral part of immunology but the
route from discovery of “suppressive” lymphocytes in the 1980s to the current established …

Regulatory T (Treg) cells play a crucial role in maintaining peripheral tolerance and
preventing autoimmunity. However, they also represent a major barrier to effective antitumor …

CD4+ Foxp3+ T regulatory (Treg) cells control many facets of immune responses ranging
from autoimmune diseases, to inflammatory conditions, and cancer in an attempt to maintain …

Cancer immunotherapy utilizing T‐cell checkpoint inhibitors has shown tremendous clinical
success. Yet, this mode of treatment is effective in only a subset of patients. Unresponsive …

The chemokine CXCL12 and its receptor CXCR4 are expressed widely in human cancers,
including ovarian cancer, in which they are associated with disease progression at the …

This chapter reviews the current treatment of chronic and neoplastic human papillomavirus
(HPV)-associated conditions and the development of novel therapeutic approaches …