Collagen is the major component of extracellular matrix. Collagen cross-link and deposition
depend on lysyl hydroxylation, which is catalyzed by procollagen-lysine, 2-oxoglutarate 5 …

The dissemination of tumor cells to local and distant sites presents a significant challenge in
the clinical management of many solid tumors. These cells may remain dormant for months …

Background The epigenetic regulatory chemical lactate is a product of glycolysis. It can
regulate gene expression through histone lactylation, thereby promoting tumor proliferation …

Thrombolysis with tissue plasminogen activator (tPA) provides the most common therapy for
ischemic stroke onset within the past 4.5 h. However, enhanced neutrophil infiltration and …

Background Synovial fibroblasts in rheumatoid arthritis (RAFLS) exhibit a pathological
aberration of glycolysis and glutaminolysis. Henceforth, we aimed to investigate if dual …

Background Adipocytes make up the major component of breast tissue, accounting for 90%
of stromal tissue. Thus, the crosstalk between adipocytes and breast cancer cells may play a …

Targeting metabolic remodeling represents a potentially promising strategy for
hepatocellular carcinoma (HCC) therapy. In-depth understanding on the regulation of the …

The transcription variation, leading to various forms of transcripts and protein diversity,
remains largely unexplored in triple-negative breast cancers (TNBCs). Here, we presented a …

Aberrant accumulation of succinate has been detected in many cancers. However, the
cellular function and regulation of succinate in cancer progression is not completely …

Summary N 6-methyladenosine (m 6 A) plays crucial roles in regulating RNA metabolisms.
METTL16 identified as a single-component methyltransferase catalyzes m 6 A formation in …