Assessment of left ventricular systolic and diastolic pump properties is fundamental to
advancing the understanding of cardiovascular pathophysiology and therapeutics …

Triggered activity in cardiac muscle and intracellular Ca2+ have been linked in the past.
However, today not only are there a number of cellular proteins that show clear Ca2+ …

Spontaneous local increases in the concentration of intracellular calcium, called" calcium
sparks," were detected in quiescent rat heart cells with a laser scanning confocal …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

A mathematical model of the cardiac ventricular action potential is presented. In our previous
work, the membrane Na+ current and K+ currents were formulated. The present article …

Ca2+ has been postulated as a cytosolic second messenger in the regulation of cardiac
oxidative phosphorylation. This hypothesis draws support from the well-known effects of …

The action potential model presented in our accompanying article in this journal is used to
investigate phenomena that involve dynamic changes of [Ca2+] i, as described below …

We develop a point model of the cardiac myofilament (MF) to simulate a wide variety of
experimental muscle characterizations including Force-Ca relations and twitches under …

A computational model of the human left-ventricular epicardial myocyte is presented. Models
of each of the major ionic currents present in these cells are formulated and validated using …

We construct a detailed mathematical model for Ca 2+ regulation in the ventricular myocyte
that includes novel descriptions of subcellular mechanisms based on recent experimental …