Many noninvasive methods for diagnosing liver fibrosis (LF) have been proposed. To
determine the best method for diagnosing LF in nonalcoholic fatty liver disease (NAFLD), we …

Peripheral nerves injuries result in paralysis, anesthesia and lack of autonomic control of the
affected body areas. After injury, axons distal to the lesion are disconnected from the …

The serine/threonine protein phosphatases are targeted to specific subcellular locations and
substrates in part via interactions with a wide variety of regulatory proteins. Understanding …

The purpose of this review is to provide an account of the physiological substrates of cAMP-
dependent protein kinase (PKA). Discussion is limited to just over 100 unique gene products …

Objectives To evaluate the association of genetic variation with late-onset Alzheimer
disease (AD) in African Americans, including genes implicated in recent genome-wide …

The response of granulosa cells to luteinizing hormone (LH) and follicle-stimulating
hormone (FSH) is mediated mainly by cAMP/protein kinase A (PKA) signaling. Notably, the …

Activation of the canonical mitogen-activated protein kinase (MAPK) cascade by soluble
mitogens is blocked in non-adherent cells. It is also blocked in cells in which the cAMP …

Abstract Polo-like kinase 1 (Plk1) plays essential roles at multiple events during cell division,
yet little is known about its physiological substrates. In a cDNA phage display screen using …

Sterile 20 (ste20) protein is an upstream ser/thr kinase in yeast, and several mammalian
Ste20-like (MST) kinases have been identified. This review focuses on the signal …

In this study, we report the cloning and characterization of a novel human Ste20-related
kinase that we designated MST4 (accession number AF231012). The 416 amino acid full …