Exosomes as mediators of intercellular crosstalk in metabolism
Exosomes are nanoparticles secreted by all cell types and are a large component of the
broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted …
broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted …
[HTML][HTML] SARS-CoV-2 pandemic and research gaps: Understanding SARS-CoV-2 interaction with the ACE2 receptor and implications for therapy
The COVID-19 pandemic is an emerging threat to global public health. While our current
understanding of COVID-19 pathogenesis is limited, a better understanding will help us …
understanding of COVID-19 pathogenesis is limited, a better understanding will help us …
[HTML][HTML] Endothelial cell infection and dysfunction, immune activation in severe COVID-19
Rationale: Pulmonary vascular endotheliitis, perivascular inflammation, and immune
activation are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly …
activation are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly …
The role of CXCL family members in different diseases
C Zhou, Y Gao, P Ding, T Wu, G Ji - Cell Death Discovery, 2023 - nature.com
Chemokines are a large family mediating a lot of biological behaviors including chemotaxis,
tumor growth, angiogenesis and so on. As one member of this family, CXC subfamily …
tumor growth, angiogenesis and so on. As one member of this family, CXC subfamily …
Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches
Y Wang, X Zhong, X He, Z Hu, H Huang, J Chen… - Journal of Experimental …, 2023 - Springer
Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among
patients with colorectal cancer (CRC). Although immunotherapy has demonstrated …
patients with colorectal cancer (CRC). Although immunotherapy has demonstrated …
Lung expression of human angiotensin-converting enzyme 2 sensitizes the mouse to SARS-CoV-2 infection
Preclinical mouse models that recapitulate some characteristics of coronavirus disease
(COVID-19) will facilitate focused study of pathogenesis and virus–host responses. Human …
(COVID-19) will facilitate focused study of pathogenesis and virus–host responses. Human …
Remodeling the hepatic fibrotic microenvironment with emerging nanotherapeutics: a comprehensive review
X Zhao, FK Amevor, X Xue, C Wang, Z Cui… - Journal of …, 2023 - Springer
Liver fibrosis could be the last hope for treating liver cancer and remodeling of the hepatic
microenvironment has emerged as a strategy to promote the ablation of liver fibrosis. In …
microenvironment has emerged as a strategy to promote the ablation of liver fibrosis. In …
microRNAs‐based diagnostic and therapeutic applications in liver fibrosis
X Zhao, X Xue, Z Cui, F Kwame Amevor… - Wiley …, 2023 - Wiley Online Library
Liver fibrosis is a process of over‐extracellular matrix (ECM) aggregation and angiogenesis,
which develops into cirrhosis and hepatocellular carcinoma (HCC). With the increasing …
which develops into cirrhosis and hepatocellular carcinoma (HCC). With the increasing …
Ahr activation leads to attenuation of murine autoimmune hepatitis: single-cell rna-seq analysis reveals unique immune cell phenotypes and gene expression …
The aryl hydrocarbon receptor (AhR) is a ubiquitously expressed ligand-activated
transcription factor. While initially identified as an environmental sensor, this receptor has …
transcription factor. While initially identified as an environmental sensor, this receptor has …
Intercellular crosstalk of liver sinusoidal endothelial cells in liver fibrosis, cirrhosis and hepatocellular carcinoma
H Li - Digestive and Liver Disease, 2022 - Elsevier
Intercellular crosstalk among various liver cells plays an important role in liver fibrosis,
cirrhosis, and hepatocellular carcinoma (HCC). Capillarization of liver sinusoidal endothelial …
cirrhosis, and hepatocellular carcinoma (HCC). Capillarization of liver sinusoidal endothelial …