Materials Design Innovations in Optimizing Cellular Behavior on Melt Electrowritten (MEW) Scaffolds
The field of melt electrowriting (MEW) has seen significant progress, bringing innovative
advancements to the fabrication of biomaterial scaffolds, and creating new possibilities for …
advancements to the fabrication of biomaterial scaffolds, and creating new possibilities for …
[HTML][HTML] Mathematical and computational models in spheroid-based biofabrication
S Arjoca, A Robu, M Neagu, A Neagu - Acta Biomaterialia, 2023 - Elsevier
Ubiquitous in embryonic development, tissue fusion is of interest to tissue engineers who
use tissue spheroids or organoids as building blocks of three-dimensional (3D) multicellular …
use tissue spheroids or organoids as building blocks of three-dimensional (3D) multicellular …
Parameter identifiability and model selection for sigmoid population growth models
Sigmoid growth models, such as the logistic, Gompertz and Richards' models, are widely
used to study population dynamics ranging from microscopic populations of cancer cells, to …
used to study population dynamics ranging from microscopic populations of cancer cells, to …
Quantitative analysis of tumour spheroid structure
Tumour spheroids are common in vitro experimental models of avascular tumour growth.
Compared with traditional two-dimensional culture, tumour spheroids more closely mimic …
Compared with traditional two-dimensional culture, tumour spheroids more closely mimic …
Profile-wise analysis: a profile likelihood-based workflow for identifiability analysis, estimation, and prediction with mechanistic mathematical models
MJ Simpson, OJ Maclaren - PLoS Computational Biology, 2023 - journals.plos.org
Interpreting data using mechanistic mathematical models provides a foundation for
discovery and decision-making in all areas of science and engineering. Developing …
discovery and decision-making in all areas of science and engineering. Developing …
3D plotting of calcium phosphate cement and melt electrowriting of polycaprolactone microfibers in one scaffold: A hybrid additive manufacturing process
The fabrication of patient-specific scaffolds for bone substitutes is possible through extrusion-
based 3D printing of calcium phosphate cements (CPC) which allows the generation of …
based 3D printing of calcium phosphate cements (CPC) which allows the generation of …
Quantifying tissue growth, shape and collision via continuum models and Bayesian inference
Although tissues are usually studied in isolation, this situation rarely occurs in biology, as
cells, tissues and organs coexist and interact across scales to determine both shape and …
cells, tissues and organs coexist and interact across scales to determine both shape and …
[HTML][HTML] New computational tools and experiments reveal how geometry affects tissue growth in 3D printed scaffolds
Understanding how tissue growth in porous scaffolds is influenced by geometry is a
fundamental challenge in the field of tissue engineering. We investigate the influence of …
fundamental challenge in the field of tissue engineering. We investigate the influence of …
Introducing Controlled Microporosity in Melt Electrowriting
KMA Mueller, A Unterrainer… - Advanced Materials …, 2023 - Wiley Online Library
Melt electrowriting (MEW) enables the electric field‐assisted digital fabrication of precisely
defined scaffold architectures of micron‐sized fibers. However, charge accumulation and …
defined scaffold architectures of micron‐sized fibers. However, charge accumulation and …
Structural identifiability analysis of linear reaction–advection–diffusion processes in mathematical biology
AP Browning, M Taşcă, C Falcó… - Proceedings of the …, 2024 - royalsocietypublishing.org
Effective application of mathematical models to interpret biological data and make accurate
predictions often requires that model parameters are identifiable. Approaches to assess the …
predictions often requires that model parameters are identifiable. Approaches to assess the …