Supramolecular assemblies in functional siRNA delivery: where do we stand?
The discovery of RNA interference (RNAi) has excited the scientific field due to its potential
for wide range of therapeutic applications. The pharmacological mediator of RNAi, short …
for wide range of therapeutic applications. The pharmacological mediator of RNAi, short …
[HTML][HTML] Barriers to liposomal gene delivery: from application site to the target
M Saffari, HR Moghimi, CR Dass - Iranian journal of …, 2016 - ncbi.nlm.nih.gov
Gene therapy is a therapeutic approach to deliver genetic material into cells to alter their
function in entire organism. One promising form of gene delivery system (DDS) is liposomes …
function in entire organism. One promising form of gene delivery system (DDS) is liposomes …
In Vitro–In Vivo Translation of Lipid Nanoparticles for Hepatocellular siRNA Delivery
KA Whitehead, J Matthews, PH Chang, F Niroui… - ACS …, 2012 - ACS Publications
A significant challenge in the development of clinically viable siRNA delivery systems is a
lack of in vitro–in vivo translatability: many delivery vehicles that are initially promising in cell …
lack of in vitro–in vivo translatability: many delivery vehicles that are initially promising in cell …
The enhancement of gene silencing efficiency with chitosan-coated liposome formulations of siRNAs targeting HIF-1α and VEGF
RNA interference (RNAi) holds considerable promise as a novel therapeutic strategy in the
silencing of disease-causing genes. The development of effective delivery systems is …
silencing of disease-causing genes. The development of effective delivery systems is …
Efficient siRNA delivery and gene silencing using a lipopolypeptide hybrid vector mediated by a caveolae-mediated and temperature-dependent endocytic pathway
H Kasai, K Inoue, K Imamura, C Yuvienco… - Journal of …, 2019 - Springer
Background We developed a non-viral vector, a combination of HIV-1 Tat peptide modified
with histidine and cysteine (mTat) and polyethylenimine, jetPEI (PEI), displaying the high …
with histidine and cysteine (mTat) and polyethylenimine, jetPEI (PEI), displaying the high …
Anti-angiogenic therapy via cationic liposome-mediated systemic siRNA delivery
T Tagami, T Suzuki, M Matsunaga, K Nakamura… - International journal of …, 2012 - Elsevier
siRNA has been touted as a therapeutic molecule against genetic diseases, which include
cancers. But several challenging issues remain in order to achieve efficient systemic siRNA …
cancers. But several challenging issues remain in order to achieve efficient systemic siRNA …
Tumor-selective lipopolyplex encapsulated small active RNA hampers colorectal cancer growth in vitro and in orthotopic murine
LL Wang, CL Feng, WS Zheng, S Huang, WX Zhang… - Biomaterials, 2017 - Elsevier
Small active RNA (saRNA)-induced gene activation (RNAa) is a novel strategy to treat
cancer. Our previous work proved that the p21-saRNA-322 successfully hindered colorectal …
cancer. Our previous work proved that the p21-saRNA-322 successfully hindered colorectal …
siRNA delivery into tumor cells by lipid-based nanoparticles composed of hydroxyethylated cholesteryl triamine
Y Hattori, T Nakamura, H Ohno, N Fujii… - International journal of …, 2013 - Elsevier
Previously, we reported that cationic nanoparticles (NP) composed of cholesteryl diamine
(OH-Chol,(3S)-N-(2-(2-hydroxyethylamino) ethyl) cholesteryl-3-carboxamide) and Tween 80 …
(OH-Chol,(3S)-N-(2-(2-hydroxyethylamino) ethyl) cholesteryl-3-carboxamide) and Tween 80 …
The challenge of regulating nanomedicine: Key issues
R Bawa, Y Barenholz, A Owen - 2016 - books.rsc.org
There is no shortage of excitement, exuberance, hype and misinformation when it comes to
anything ''nano''. Many claim it to be the next industrial revolution, some purport that it has …
anything ''nano''. Many claim it to be the next industrial revolution, some purport that it has …
Effects of extrusion, lipid concentration and purity on physico-chemical and biological properties of cationic liposomes for gene vaccine applications
T de Paula Rigoletto, CL Silva… - Journal of …, 2012 - Taylor & Francis
We developed cationic liposomes containing DNA through a conventional process involving
steps of (i) preformation of liposomes,(ii) extrusion,(iii) drying and rehydration and (iv) DNA …
steps of (i) preformation of liposomes,(ii) extrusion,(iii) drying and rehydration and (iv) DNA …