Exercise mimetics are a proposed class of therapeutics that specifically mimic or enhance
the therapeutic effects of exercise. Increased physical activity has demonstrated positive …

Alzheimer's disease (AD) is a common neurodegenerative disorder that presents with
cognitive impairment and behavioral disturbance. Approximately 5.5 million people in the …

Lifestyle may be one source of unexplained variance in the great interindividual variability of
the brain in age-related structural differences. While physical and social activity may protect …

The societal value of strategies that delay the onset and progression of dementia cannot be
overstated. Physical activity—unstructured and structured—is a promising, cost-effective …

Spinal cord injury is a devastating condition that is followed by long and often unsuccessful
recovery after trauma. The state of the art approach to manage paralysis and concomitant …

Circulating BDNF is higher in women than in men and suggested to be affected by changes
in food intake, body weight, and exercise. The purpose of this study was to compare BDNF …

Aerobic training (AT) is a promising, non-pharmacological intervention to mitigate the
deleterious effects of aging and disease on brain health. However, a large amount of …

Rationale Exposure to social defeat (SD) induces a depressive phenotype, increased
ethanol seeking and consumption, accompanied by activation of the neuroinflammatory …

Exercise is known to have a myriad of health benefits. There is much to be learned from the
effects of exercise and its potential for prevention, attenuation and treatment of multiple …

Research in humans indicates that women may show greater cognitive benefits from aerobic
training (AT) than men. To determine whether this sex difference extends to rodents, we …