Hippocampal sclerosis (HS) is a common pathology encountered in mesial temporal lobe
epilepsy (MTLE) as well as other epilepsy syndromes and in both surgical and post‐mortem …

The tumor suppressor p53 is one of the most frequently mutated genes in human cancers.
MicroRNAs (miRNAs) are small non-protein coding RNAs that regulate gene expression on …

Background Temporal lobe epilepsy is a common and frequently intractable seizure
disorder. Its pathogenesis is thought to involve large-scale alterations to the expression of …

Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …

The mir-34 family was originally cloned and characterized in 2007 as a p53 target gene.
Almost immediately it became clear that its major role is as a master regulator of tumor …

Background The expression pattern and function of miRNAs in the rat model of temporal
lobe epilepsy have not been well defined. Profiling miRNA expression in the rat model of …

MicroRNAs (miRNAs) are rapidly emerging as central regulators of gene expression in the
postnatal mammalian brain. Initial studies mostly focused on the function of specific miRNAs …

Mesial temporal lobe epilepsy (MTLE) is a particularly devastating form of human epilepsy
with significant incidence of medical intractability. MicroRNAs (miRs) are small, noncoding …

MicroRNAs (miRNAs) are endogenous,∼ 22 nucleotide, non-coding RNA molecules that
function as post-transcriptional regulators of gene expression. miRNA dysregulation has …

Vascular pathology is the second most common neuropathology of dementia after
Alzheimer's disease (AD), with small vessels disease (SVD) being considered the major …