PCL-based composite scaffold matrices for tissue engineering applications

N Siddiqui, S Asawa, B Birru, R Baadhe, S Rao - Molecular biotechnology, 2018 - Springer
Biomaterial-based scaffolds are important cues in tissue engineering (TE) applications.
Recent advances in TE have led to the development of suitable scaffold architecture for …

[HTML][HTML] Multiphasic scaffolds for the repair of osteochondral defects: outcomes of preclinical studies

R Chen, JS Pye, J Li, CB Little, JJ Li - Bioactive Materials, 2023 - Elsevier
Osteochondral defects are caused by injury to both the articular cartilage and subchondral
bone within skeletal joints. They can lead to irreversible joint damage and increase the risk …

Injectable natural polymer hydrogels for treatment of knee osteoarthritis

X Lin, CT Tsao, M Kyomoto… - Advanced healthcare …, 2022 - Wiley Online Library
Osteoarthritis (OA) is a serious chronic and degenerative disease that increasingly occurs in
the aged population. Its current clinical treatments are limited to symptom relief and cannot …

[HTML][HTML] Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells (ESPCs)-mediated articular cartilage repair

L Zhou, J Xu, A Schwab, W Tong, J Xu, L Zheng, Y Li… - Bioactive Materials, 2023 - Elsevier
As a highly specialized shock-absorbing connective tissue, articular cartilage (AC) has very
limited self-repair capacity after traumatic injuries, posing a heavy socioeconomic burden …

In-situ forming injectable GFOGER-conjugated BMSCs-laden hydrogels for osteochondral regeneration

MY Ha, DH Yang, SJ You, HJ Kim… - npj Regenerative …, 2023 - nature.com
The collagen-mimetic peptide GFOGER possesses the chondrogenic potential and has
been used as a cell adhesion peptide or chondrogenic inducer. Here, we prepared an …

3D printed multiphasic scaffolds for osteochondral repair: challenges and opportunities

SE Doyle, F Snow, S Duchi, CD O'connell… - International Journal of …, 2021 - mdpi.com
Osteochondral (OC) defects are debilitating joint injuries characterized by the loss of full
thickness articular cartilage along with the underlying calcified cartilage through to the …

Healing of osteochondral defects implanted with biomimetic scaffolds of poly (ε-caprolactone)/hydroxyapatite and glycidyl-methacrylate-modified hyaluronic acid in a …

YH Hsieh, BY Shen, YH Wang, B Lin, HM Lee… - International Journal of …, 2018 - mdpi.com
Articular cartilage is a structure lack of vascular distribution. Once the cartilage is injured or
diseased, it is unable to regenerate by itself. Surgical treatments do not effectively heal …

Hyperbranched polymer-based nanoparticle drug delivery platform for the nucleus-targeting in cancer therapy

A Bal-Öztürk, SD Tietilu, O Yücel, T Erol… - Journal of Drug Delivery …, 2023 - Elsevier
Hyperbranched polymers (HPB) are drawing attention as one of the drug delivery platforms
that can encapsulate drugs owing to the internal voids in their three-dimensional construct. It …

Layer-by-layer self-assembly and clinical application in orthopedics

X Ma, D Zhao, Y Xiang, Y Hua, W Zhao, Y Cui… - Journal of Materials …, 2023 - Elsevier
Orthopedic implants for the treatment of bone defects from various causes have been
challenged by insufficient osseointegration, bacterial infection, oxidative stress, immune …

When electrospun fiber support matters: in vitro ovine long-term folliculogenesis on poly (epsilon caprolactone)(PCL)-patterned fibers

C Di Berardino, L Liverani, A Peserico, G Capacchietti… - Cells, 2022 - mdpi.com
Current assisted reproduction technologies (ART) are insufficient to cover the slice of the
population needing to restore fertility, as well as to amplify the reproductive performance of …