Steatotic liver disease: pathophysiology and emerging pharmacotherapies

M Kokkorakis, E Muzurović, Š Volčanšek… - Pharmacological …, 2024 - Elsevier
Steatotic liver disease (SLD) displays a dynamic and complex disease phenotype.
Consequently, the metabolic dysfunction-associated steatotic liver disease …

Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis

B Tan, XH Pan, HSJ Chew, RSJ Goh, C Lin… - International Journal of …, 2023 - nature.com
Background Recent studies suggest that tirzepatide, a dual glucose-dependent
insulinotropic-peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA), has …

Global burden of metabolic diseases, 1990–2021

H Zhang, XD Zhou, MD Shapiro, GYH Lip, H Tilg… - Metabolism, 2024 - Elsevier
Background Common metabolic diseases, such as type 2 diabetes mellitus (T2DM),
hypertension, obesity, hypercholesterolemia, and metabolic dysfunction-associated steatotic …

Disparities in metabolic dysfunction-associated steatotic liver disease and cardiometabolic conditions in low and lower middle-income countries: a systematic analysis …

P Danpanichkul, K Suparan, P Dutta, C Kaeosri… - Metabolism, 2024 - Elsevier
Objective Metabolic dysfunction-associated steatotic liver disease (MASLD) and
cardiometabolic conditions affect populations across economic strata. Nevertheless, there …

Global burden of cardiovascular diseases: projections from 2025 to 2050

B Chong, J Jayabaskaran, SM Jauhari… - European Journal of …, 2024 - academic.oup.com
Aims The prediction of future trends in cardiovascular disease (CVD) mortality and their risk
factors can assist policy-makers in healthcare planning. This study aims to project geospatial …

Milestones in the journey towards addressing obesity; Past trials and triumphs, recent breakthroughs, and an exciting future in the era of emerging effective medical …

M Kokkorakis, A Katsarou, N Katsiki, CS Mantzoros - Metabolism, 2023 - Elsevier
The 21st century is characterized by an increasing incidence and prevalence of obesity and
the burden of its associated comorbidities, especially cardiometabolic diseases, which are …

[HTML][HTML] The burden of cardiovascular disease in Asia from 2025 to 2050: a forecast analysis for East Asia, South Asia, South-East Asia, Central Asia, and high-income …

RSJ Goh, B Chong, J Jayabaskaran… - The Lancet Regional …, 2024 - thelancet.com
Background Given the rapidly growing burden of cardiovascular disease (CVD) in Asia, this
study forecasts the CVD burden and associated risk factors in Asia from 2025 to 2050 …

Epicardial adipose tissue assessed by computed tomography and echocardiography are associated with adverse cardiovascular outcomes: a systematic review and …

B Chong, J Jayabaskaran, J Ruban, R Goh… - Circulation …, 2023 - Am Heart Assoc
Background: Epicardial adipose tissue (EAT) has garnered attention as a prognostic and
risk stratification factor for cardiovascular disease. This study, via meta-analyses, evaluates …

Protein kinases: The key contributors in pathogenesis and treatment of nonalcoholic fatty liver disease-derived hepatocellular carcinoma

R Liu, MP Qian, YY Cui - Metabolism, 2023 - Elsevier
Protein kinases (PKs), one of the largest protein families, can be further divided into different
groups based on their substrate or structure and function. PKs are important signaling …

The silent burden of non‐alcoholic fatty liver disease in the elderly: a global burden of disease analysis

P Danpanichkul, CH Ng, MD Muthiah… - Alimentary …, 2023 - Wiley Online Library
Background Non‐alcoholic fatty liver disease (NAFLD) represents a significant health threat
worldwide. The growing trend towards an aging population, along with an alarming rise in …