▪ Abstract Src family protein tyrosine kinases are activated following engagement of many
different classes of cellular receptors and participate in signaling pathways that control a …

Phosphatidylinositol, a component of eukaryotic cell membranes, is unique among
phospholipids in that its head group can be phosphorylated at multiple free hydroxyls …

Ras (p21 ras) interacts directly with the catalytic subunit of phosphatidylinositol-3-OH kinase
in a GTP-dependent manner through the Ras effector site. In vivo, dominant negative Ras …

The function and activity of a protein are often modulated by other proteins with which it
interacts. This review is intended as a practical guide to the analysis of such protein-protein …

Src is the best understood member of a family of 9 tyrosine kinases that regulates cellular
responses to extracellular stimuli. Activated mutants of Src are oncogenic. Using Src as an …

Many studies have shown the central importance of the co-receptors CD28, inducible
costimulatory molecule (ICOS) and cytotoxic T lymphocyte antigen 4 (CTLA4) in the …

▪ Abstract The T cell antigen receptor (TCR) regulates the activation and growth of T
lymphocytes. The initial membrane proximal event triggered by the TCR is activation of …

Abstract THE RNA polymerase II general transcription factor TFIIH is composed of several
polypeptides. The observation that the largest subunit of TFIIH is the excision-repair protein …

Because hematopoietic cells express multiple Fc gamma receptor isoforms, the role of the
individual Fc gamma receptors in phagocytosis has been difficult to define. Transfection of …

Ligation of the T cell receptor for antigen (TCR) and/or costimulatory receptor CD28 results
in rapid activation of phosphoinositide‐3 kinase (PI‐3 kinase). It remains unclear, however …