Acetals and ketals and their nitrogen and sulfur homologues are often considered to be
unconventional and potentially problematic scaffolding elements or pharmacophores for the …

A major challenge in cancer therapy is tumor drug resistance. To overcome it, it is essential
to understand the mechanisms and identify the molecules involved, so that they can be …

This article provides an overview on the recent achievements to combat Gram-positive
bacteria and the mechanisms related to antimicrobial activity and bacterial resistance …

The oxazolidinones are a promising new class of synthetic antibacterial agents. Here, we
review recent efforts directed at the discovery of new antibacterial compounds of this class …

Isoxazol-5-ones and isoxazolidin-5-ones represent two important classes of heterocycles,
with several applications as bioactive compounds and as versatile building blocks for further …

Herein, we report the development of metal-free one/two-pot procedures for the synthesis of
benzo [c] isoxazol-3 (1 H)-one (benzisoxazolone) heterocycles by designing diaryliodonium …

Histone deacetylases (HDACs) have the ability to cleave the acetyl groups of ε‐N‐acetylated
lysine residues in a variety of proteins. Given that human cells contain thousands of different …

The development of resistance by the antibiotics in the Gram-positive pathogenic bacteria
over the last twenty years and continuing today has created a need for new antibiotic …

A thiourea‐Brønsted base bifunctional catalyst allowed the enantioselective 1, 6‐aza‐
Michael addition of isoxazolin‐5‐ones to p‐quinone methides to give isoxazolin‐5‐ones …

1, 4-Conjugate addition of ((chloromethyl) sulfonyl) benzenes to arylideneisoxazol-5-ones,
followed by one-pot, N-selective trapping in the presence of electrophiles, was investigated …