Robustness: linking strain design to viable bioprocesses
Microbial cell factories are becoming increasingly popular for the sustainable production of
various chemicals. Metabolic engineering has led to the design of advanced cell factories; …
various chemicals. Metabolic engineering has led to the design of advanced cell factories; …
Compensatory epistasis maintains ACE2 affinity in SARS-CoV-2 Omicron BA. 1
The Omicron BA. 1 variant emerged in late 2021 and quickly spread across the world.
Compared to the earlier SARS-CoV-2 variants, BA. 1 has many mutations, some of which …
Compared to the earlier SARS-CoV-2 variants, BA. 1 has many mutations, some of which …
Best practices in designing, sequencing, and identifying random DNA barcodes
Random DNA barcodes are a versatile tool for tracking cell lineages, with applications
ranging from development to cancer to evolution. Here, we review and critically evaluate …
ranging from development to cancer to evolution. Here, we review and critically evaluate …
Mutualism-enhancing mutations dominate early adaptation in a two-species microbial community
Species interactions drive evolution while evolution shapes these interactions. The resulting
eco-evolutionary dynamics and their repeatability depend on how adaptive mutations …
eco-evolutionary dynamics and their repeatability depend on how adaptive mutations …
Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation
Building a genotype-phenotype-fitness map of adaptation is a central goal in evolutionary
biology. It is difficult even when adaptive mutations are known because it is hard to …
biology. It is difficult even when adaptive mutations are known because it is hard to …
The landscape of antibody binding affinity in SARS-CoV-2 Omicron BA. 1 evolution
The Omicron BA. 1 variant of SARS-CoV-2 escapes convalescent sera and monoclonal
antibodies that are effective against earlier strains of the virus. This immune evasion is …
antibodies that are effective against earlier strains of the virus. This immune evasion is …
Emergent evolutionary forces in spatial models of luminal growth and their application to the human gut microbiota
The genetic composition of the gut microbiota is constantly reshaped by ecological and
evolutionary forces. These strain-level dynamics are challenging to understand because …
evolutionary forces. These strain-level dynamics are challenging to understand because …
Idiosyncratic epistasis leads to global fitness–correlated trends
Epistasis can markedly affect evolutionary trajectories. In recent decades, protein-level
fitness landscapes have revealed extensive idiosyncratic epistasis among specific …
fitness landscapes have revealed extensive idiosyncratic epistasis among specific …
[HTML][HTML] Deterministic evolution and stringent selection during preneoplasia
The earliest events during human tumour initiation, although poorly characterized, may hold
clues to malignancy detection and prevention. Here we model occult preneoplasia by …
clues to malignancy detection and prevention. Here we model occult preneoplasia by …
Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast
Mapping the genetic basis of complex traits is critical to uncovering the biological
mechanisms that underlie disease and other phenotypes. Genome-wide association studies …
mechanisms that underlie disease and other phenotypes. Genome-wide association studies …