Similarities between disuse and age‐induced bone loss

EG Buettmann, GM Goldscheitter… - Journal of Bone and …, 2022 - Wiley Online Library
Disuse and aging are known risk factors associated with low bone mass and quality
deterioration, resulting in increased fracture risk. Indeed, current and emerging evidence …

International roadmap for artificial gravity research

G Clément - npj Microgravity, 2017 - nature.com
In this paper, we summarize the current and future research activities that will determine the
requirements for implementing artificial gravity (AG) to mitigate the effects of long duration …

The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes

JS Willey, RA Britten, E Blaber… - … Science and Health …, 2021 - Taylor & Francis
Both microgravity and radiation exposure in the spaceflight environment have been
identified as hazards to astronaut health and performance. Substantial study has been …

Impairment of 7F2 osteoblast function by simulated partial gravity in a Random Positioning Machine

J Braveboy-Wagner, PI Lelkes - NPJ microgravity, 2022 - nature.com
The multifaceted adverse effects of reduced gravity pose a significant challenge to human
spaceflight. Previous studies have shown that bone formation by osteoblasts decreases …

Synergistic interplay between radiation and microgravity in spaceflight-related immunological health risks

A Wadhwa, M Moreno-Villanueva, B Crucian, H Wu - Immunity & Ageing, 2024 - Springer
Spaceflight poses a myriad of environmental stressors to astronauts´ physiology including
microgravity and radiation. The individual impacts of microgravity and radiation on the …

Impact of anti-gravity treadmill rehabilitation therapy on the clinical outcomes after fixation of lower limb fractures: A randomized clinical trial

R Henkelmann, L Palke, S Schneider… - Clinical …, 2021 - journals.sagepub.com
Objective: To compare the effects of anti-gravity treadmill rehabilitation with those of
standard rehabilitation on surgically treated ankle and tibial plateau fractures. Design: Open …

Combined effects of simulated microgravity and radiation exposure on osteoclast cell fusion

S Shanmugarajan, Y Zhang… - International Journal of …, 2017 - mdpi.com
The loss of bone mass and alteration in bone physiology during space flight are one of the
major health risks for astronauts. Although the lack of weight bearing in microgravity is …

Simulating the lunar environment: partial weightbearing and high-LET radiation-induce bone loss and increase sclerostin-positive osteocytes

BR Macias, F Lima, JM Swift… - Radiation …, 2016 - meridian.allenpress.com
Exploration missions to the Moon or Mars will expose astronauts to galactic cosmic radiation
and low gravitational fields. Exposure to reduced weightbearing and radiation …

Approaching gravity as a continuum using the rat partial weight-bearing model

M Mortreux, ME Rosa-Caldwell - Life, 2020 - mdpi.com
For decades, scientists have relied on animals to understand the risks and consequences of
space travel. Animals remain key to study the physiological alterations during spaceflight …

Revisiting the needs for artificial gravity during deep space missions

GR Clément, JB Charles, WH Paloski - Reach, 2016 - Elsevier
In the past 15 years, several group studies have identified the need to validate the role of
artificial gravity (AG) as countermeasure to physiological deconditioning during long …