Combination chemotherapy can cure certain leukemias and lymphomas, but most solid cancers are only curable at early stages. We review quantitative principles that explain the …
Cisplatin and its platinum analogs, carboplatin and oxaliplatin, are some of the most widely used cancer chemotherapeutics. Although cisplatin and carboplatin are used primarily in …
Traditionally, intertumour heterogeneity in breast cancer has been documented in terms of different histological subtypes, treatment sensitivity profiles, and clinical outcomes among …
Our understanding of cancer is being transformed by exploring clonal diversity, drug resistance, and causation within an evolutionary framework. The therapeutic resilience of …
M Kibble, N Saarinen, J Tang, K Wennerberg… - Natural product …, 2015 - pubs.rsc.org
Covering: 2011 to 2014 It is widely accepted that drug discovery often requires a systems- level polypharmacology approach to tackle problems such as lack of efficacy and emerging …
Cancer drug resistance is a major problem, with the majority of patients with metastatic disease ultimately developing multidrug resistance and succumbing to their disease. Our …
W Kolch, M Halasz, M Granovskaya… - Nature Reviews …, 2015 - nature.com
Cancer is often considered a genetic disease. However, much of the enormous plasticity of cancer cells to evolve different phenotypes, to adapt to challenging microenvironments and …
JF Hastings, JN Skhinas, D Fey… - British journal of …, 2019 - Wiley Online Library
The extracellular matrix (ECM) is a salient feature of all solid tissues within the body. This complex, acellular entity is composed of hundreds of individual molecules whose assembly …
F Azuaje - Briefings in bioinformatics, 2017 - academic.oup.com
The computational prediction of drug responses based on the analysis of multiple types of genome-wide molecular data is vital for accomplishing the promise of precision medicine in …