Electrical stimulation for the treatment of spinal cord injuries: A review of the cellular and molecular mechanisms that drive functional improvements

RM Dorrian, CF Berryman, A Lauto… - Frontiers in Cellular …, 2023 - frontiersin.org
Spinal cord injury (SCI) is a devastating condition that causes severe loss of motor, sensory
and autonomic functions. Additionally, many individuals experience chronic neuropathic …

Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease

AK Vose, JF Welch, J Nair, EA Dale, EJ Fox… - Experimental …, 2022 - Elsevier
We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

[HTML][HTML] Walking naturally after spinal cord injury using a brain–spine interface

H Lorach, A Galvez, V Spagnolo, F Martel, S Karakas… - Nature, 2023 - nature.com
A spinal cord injury interrupts the communication between the brain and the region of the
spinal cord that produces walking, leading to paralysis,. Here, we restored this …

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

A Rowald, S Komi, R Demesmaeker, E Baaklini… - Nature medicine, 2022 - nature.com
Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments
restores walking in people with spinal cord injury (SCI). However, EES is delivered with …

Transcutaneous spinal cord stimulation restores hand and arm function after spinal cord injury

F Inanici, LN Brighton, S Samejima… - … on Neural Systems …, 2021 - ieeexplore.ieee.org
Paralysis of the upper extremity severely restricts independence and quality of life after
spinal cord injury. Regaining control of hand and arm movements is the highest treatment …

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

JW Squair, M Gautier, L Mahe, JE Soriano, A Rowald… - Nature, 2021 - nature.com
Spinal cord injury (SCI) induces haemodynamic instability that threatens survival,–, impairs
neurological recovery,, increases the risk of cardiovascular disease,, and reduces quality of …

Epidural spinal cord stimulation as an intervention for motor recovery after motor complete spinal cord injury

JT Hachmann, A Yousak, JJ Wallner… - Journal of …, 2021 - journals.physiology.org
Spinal cord injury (SCI) commonly results in permanent loss of motor, sensory, and
autonomic function. Recent clinical studies have shown that epidural spinal cord stimulation …

[HTML][HTML] Circuit reconstruction of newborn neurons after spinal cord injury in adult rats via an NT3-chitosan scaffold

Z Wang, H Duan, F Hao, P Hao, W Zhao, Y Gao… - Progress in …, 2023 - Elsevier
Abstract An implanted neurotrophin-3 (NT3)-chitosan scaffold can recruit endogenous
neural stem cells to migrate to a lesion region and differentiate into mature neurons after …

Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial

C Moritz, EC Field-Fote, C Tefertiller, I van Nes… - Nature medicine, 2024 - nature.com
Cervical spinal cord injury (SCI) leads to permanent impairment of arm and hand functions.
Here we conducted a prospective, single-arm, multicenter, open-label, non-significant risk …

Consequences of spinal cord injury on the sympathetic nervous system

MJ Wulf, VJ Tom - Frontiers in cellular neuroscience, 2023 - frontiersin.org
Spinal cord injury (SCI) damages multiple structures at the lesion site, including ascending,
descending, and propriospinal axons; interrupting the conduction of information up and …