Tissue morphogenesis requires the collective, coordinated motion and deformation of a
large number of cells. Vertex model simulations for tissue mechanics have been developed …

D'Arcy Thompson was a proponent of applying mathematical and physical principles to
biological systems, an approach that is becoming increasingly common in developmental …

Embryonic epithelia achieve complex morphogenetic movements, including in-plane
reshaping, bending and folding, through the coordinated action and rearrangement of …

Cell apical constriction driven by actomyosin contraction forces is a conserved mechanism
during tissue folding in embryo development. While much is now understood of the …

During Drosophila gastrulation, the ventral mesodermal cells constrict their apices, undergo
a series of coordinated cell-shape changes to form a ventral furrow (VF) and are …

A major problem in biology is to understand how complex tissue shapes may arise through
growth. In many cases this process involves preferential growth along particular orientations …

Tissue folding promotes three-dimensional (3D) form during development. In many cases,
folding is associated with myosin accumulation at the apical surface of epithelial cells, as …

Epithelial− mesenchymal transition (EMT) is an essential process both in physiological and
pathological contexts. Intriguingly, EMT is often associated with tissue invagination during …

Epithelial monolayers are the simplest tissues in multicellular organisms, yet they play a vital
role in many physiological processes, including development, growth, and wound healing …

In the developing embryo, tissues differentiate, deform, and move in an orchestrated manner
to generate various biological shapes driven by the complex interplay between genetic …