Most patients with multiple myeloma (MM) present with symptoms, have evidence of
generalized disease, and require chemotherapy promptly to reduce the malignant clone …

Multiple myeloma (MM), a malignant tumor of somatically mutated, isotype-switched plasma
cells (PC), usually arises from a common benign PC tumor called Monoclonal Gammopathy …

Previously we reported that a karyotypically silent t (4; 14)(p16. 3; q32. 3) translocation is
present in about 25% of multiple myeloma (MM) tumors, and causes overexpression of …

Using sequential gene expression profiling (GEP) samples, we defined a major functional
group related to drug resistance that contains chromosomal instability (CIN) genes. One CIN …

Conventional karyotypes performed before any treatment in 208 patients with multiple
myeloma were reviewed by the Groupe Français de Cytogénétique Hématologique. A total …

Translocations involving c-myc and an Ig locus have been reported rarely in human multiple
myeloma (MM). Using specific fluorescence in situ hybridization probes, we show complex …

In multiple myeloma (MM), previous studies showed that mutations of the p53 gene are rare
events in patients with newly diagnosed disease, but it is not known whether deletions of …

Our knowledge of myeloma genetics remained limited and lagged behind many other
hematologic malignancies because of the inherent difficulties in generating metaphases …

The pathogenesis of multiple myeloma (MM), an incurable tumour causing the deregulated
proliferation of terminally differentiated B cells, is unknown1. Chromosomal translocations …

PURPOSE: To review the clinical features, complications, and treatment of Waldenström's
macroglobulinemia, a low-grade lymphoproliferative disorder that produces monoclonal …