Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …

Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …

Dengue is a significant global health problem. Even though a vaccine against dengue is
now available, which is a notable achievement, its long-term protective efficacy against each …

Highlights•Evaluating drug efficacy, specificity and toxicity may help to develop an optimal
treatment regime for in vivo studies.•Measuring time to resolve viremia in vivo may help to …

In recent years the emergence and resurgence of arboviruses have generated a global
health alert. Among arboviruses, Dengue (DENV), Zika (ZIKV), Yellow Fever (YFV), and …

Highlights•Flavivirus replication occurs on modified ER membranes called vesicle packets
(Vp) and membrane vesicles (Ve).•Flavivirus non-structural proteins are implicated in …

Flaviviruses, including Dengue (DENV), Zika (ZIKV), and Yellow Fever (YFV) viruses,
represent a significant global health burden. The development of effective antiviral therapies …

Flaviviruses are emerging arthropod-borne pathogens that cause life-threatening diseases
such as yellow fever, dengue, West Nile encephalitis, tick-borne encephalitis, Kyasanur …

The dengue virus and related flaviviruses are an increasing global health threat. In this
perspective, we comment on and review medicinal chemistry efforts aimed at the prevention …

Background. Dengue endangers billions of people in the tropical world, yet no therapeutic is
currently available. In part, the severe manifestations of dengue reflect inflammatory …