Significance of hyperreflective foci as an optical coherence tomography biomarker in retinal diseases: characterization and clinical implications

S Fragiotta, S Abdolrahimzadeh… - Journal of …, 2021 - Wiley Online Library
Hyperreflective foci (HRF) is a term coined to depict hyperreflective dots or roundish lesions
within retinal layers visualized through optical coherence tomography (OCT) …

[HTML][HTML] AI-based monitoring of retinal fluid in disease activity and under therapy

U Schmidt-Erfurth, GS Reiter, S Riedl… - Progress in retinal and …, 2022 - Elsevier
Retinal fluid as the major biomarker in exudative macular disease is accurately visualized by
high-resolution three-dimensional optical coherence tomography (OCT), which is used …

The role of intravitreal corticosteroids in the treatment of DME: predictive OCT biomarkers

MR Munk, GM Somfai, MD de Smet, G Donati… - International journal of …, 2022 - mdpi.com
This work aims to summarize predictive biomarkers to guide treatment choice in DME.
Intravitreal anti-VEGF is considered the gold standard treatment for centers involving DME …

The application of structural retinal biomarkers to evaluate the effect of intravitreal ranibizumab and dexamethasone intravitreal implant on treatment of diabetic …

I Ceravolo, GW Oliverio, A Alibrandi, A Bhatti… - Diagnostics, 2020 - mdpi.com
Background: The aim of this study was to compare the therapeutic effect of intravitreal
treatment with ranibizumab and dexamethasone using specific swept-source optical …

Neuroinflammation and neurodegeneration in diabetic retinopathy

L Bianco, A Arrigo, E Aragona, A Antropoli… - Frontiers in Aging …, 2022 - frontiersin.org
Diabetic retinopathy (DR) is the most common complication of diabetes and has been
historically regarded as a microangiopathic disease. Now, the paradigm is shifting toward a …

Joint segmentation of multi-class hyper-reflective foci in retinal optical coherence tomography images

C Yao, M Wang, W Zhu, H Huang, F Shi… - IEEE Transactions …, 2021 - ieeexplore.ieee.org
Hyper-reflective foci (HRF) refers to the spot-shaped, block-shaped areas with
characteristics of high local contrast and high reflectivity, which is mostly observed in retinal …

The long pentraxin PTX3 as a new biomarker and pharmacological target in age-related macular degeneration and diabetic retinopathy

M Stravalaci, M Ferrara, V Pathak, F Davi… - Frontiers in …, 2022 - frontiersin.org
Age related macular degeneration (AMD) and diabetic retinopathy (DR) are multifactorial,
neurodegenerative and inflammatory diseases of the eye primarily involving cellular and …

Automatic segmentation of hyperreflective foci in OCT images based on lightweight DBR network

J Wei, S Yu, Y Du, K Liu, Y Xu, X Xu - Journal of Digital Imaging, 2023 - Springer
Hyperreflective foci (HF) reflects inflammatory responses for fundus diseases such as
diabetic macular edema (DME), retina vein occlusion (RVO), and central serous …

Fast and automated hyperreflective foci segmentation based on image enhancement and improved 3D U-Net in SD-OCT volumes with diabetic retinopathy

S Xie, IP Okuwobi, M Li, Y Zhang… - … Vision Science & …, 2020 - tvst.arvojournals.org
Purpose: To design a robust and automated hyperreflective foci (HRF) segmentation
framework for spectral-domain optical coherence tomography (SD-OCT) volumes, especially …

imaging in ophthalmology

M Ferrara, Y Zheng, V Romano - Journal of Clinical Medicine, 2022 - mdpi.com
Over the last decade, ophthalmology has significantly benefited from advances in vivo non-
invasive ophthalmic imaging techniques that play currently a fundamental role in the clinical …