▪ Abstract Virtually every cell type in metazoan organisms produces heparan sulfate. These
complex polysaccharides provide docking sites for numerous protein ligands and receptors …

Chondroitin sulfate (CS) is a member of glycosaminoglycans (GAGs) and has critical
physiological functions. CS is widely applied in medical and clinical fields. Currently, the …

Herpes simplex virus type 1 (HSV-1) binds to cells through interactions of viral glycoproteins
gB and gC with heparan sulfate chains on cell surface proteoglycans. This binding is not …

J. Clin. Invest. 108: 169–173 (2001). DOI: 10.1172/JCI200113530. terms of disaccharide
composition; the disaccharides are distinguished by the presence of variably sulfated or …

Proteoglycans are widely expressed in animal cells. Interactions between negatively
charged glycosaminoglycan chains and molecules such as growth factors are essential for …

The sulfonation of endogenous molecules is a pervasive biological phenomenon that is not
always easily understood, and although it is increasingly recognized as a function of …

Heparan sulfate (HS) is ubiquitously expressed on cell surfaces and in the extracellular
matrix. HS is a highly negatively charged polysaccharide. Hundreds of proteins have …

Many protein ligands bind to heparan sulfate, which results in their presentation, protection,
oligomerization or conformational activation. Binding depends on the pattern of sulfation and …

We have performed a screening analysis of differential gene expression using a defined in
vitro model of human capillary tube formation. Gene array, differential display and cDNA …

Most of the sulfotransferases participating in glycosaminoglycan biosynthesis have now
been identified. Their essential role in generating binding sites for proteins interacting with …