Advances in nanoparticle-based mRNA delivery for liver cancer and liver-associated infectious diseases

S Chung, CM Lee, M Zhang - Nanoscale horizons, 2023 - pubs.rsc.org
The liver is a vital organ that functions to detoxify the body. Liver cancer and infectious
diseases such as influenza and malaria can fatally compromise liver function. mRNA …

[HTML][HTML] Interleukin-38 in health and disease

DM de Graaf, LU Teufel, LAB Joosten, CA Dinarello - Cytokine, 2022 - Elsevier
This review examines the role of interleukin (IL)-38 in health and disease. IL-38 functions as
an anti-inflammatory cytokine in the IL-1 family, with properties comparable to IL-37, another …

Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma

X Sun, T Hou, E Cheung, TNT Iu, VWH Tam… - Cellular & molecular …, 2020 - nature.com
We elucidated the anti-inflammatory mechanisms of IL-38 in allergic asthma. Human
bronchial epithelial cells and eosinophils were cocultured upon stimulation with the viral …

[HTML][HTML] Multifaceted roles of IL-38 in inflammation and cancer

A Diaz-Barreiro, A Huard, G Palmer - Cytokine, 2022 - Elsevier
Abstract Interleukin (IL)-38 is the least well-understood cytokine of the IL-1 family. Since its
discovery twenty years ago, numerous studies have linked IL-38 to diverse pathologies …

The emerging role of IL‐38 in diseases: A comprehensive review

W Chen, S Xi, Y Ke, Y Lei - Immunity, Inflammation and …, 2023 - Wiley Online Library
Abstract Introduction Interleukin‐38 (IL‐38) is a new type of anti‐inflammatory cytokine,
which is mainly expressed in the immunity‐related organs and is involved in various …

Interleukin‐38 alleviates hepatic steatosis through AMPK/autophagy‐mediated suppression of endoplasmic reticulum stress in obesity models

JL Sun, W Cho, H Oh, AM Abd El‐Aty… - Journal of Cellular …, 2024 - Wiley Online Library
Abstract Interleukin‐38 (IL‐38), recently recognized as a cytokine with anti‐inflammatory
properties that mitigate type 2 diabetes, has been associated with indicators of insulin …

Reduced concentrations of the B cell cytokine interleukin 38 are associated with cardiovascular disease risk in overweight subjects

DM de Graaf, M Jaeger… - European Journal of …, 2021 - Wiley Online Library
The IL‐1 family member IL‐38 (IL1F10) suppresses inflammatory and autoimmune
conditions. Here, we report that plasma concentrations of IL‐38 in 288 healthy Europeans …

Interleukin-38 in atherosclerosis

XH Zhang, Y Li, L Zhou, GP Tian - Clinica Chimica Acta, 2022 - Elsevier
Chronic inflammation caused by immune cells and their mediators is a characteristic of
atherosclerosis. Interleukin-38 (IL-38), a member of the IL-1 family, exerts multiple anti …

Interleukin-38 overexpression in keratinocytes limits desquamation but does not affect the global severity of imiquimod-induced skin inflammation in mice

A Huard, E Rodriguez, D Talabot-Ayer… - Frontiers in …, 2024 - frontiersin.org
Psoriasis is a common chronic inflammatory skin disease that significantly impacts the
patients' quality of life. Recent studies highlighted the function of the interleukin (IL)-1 family …

Clinical relevance and therapeutic potential of IL-38 in immune and non-immune-related disorders

MR Haghshenas, MR Zamir, M Sadeghi… - European cytokine …, 2022 - Springer
Abstract Interleukin-38 (IL-38) is the most recent member of the IL-1 family that acts as a
natural inflammatory inhibitor by binding to cognate receptors, particularly the IL-36 receptor …