Simple Summary Spine metastases are a common life-threatening complication of
advanced-stage malignancies and often result in poor prognosis. Symptomatic spine …

The SMAD-specific E3 ubiquitin protein ligase 2 (SMURF2) has emerged as a critical
regulator in cancer biology, modulating the stability of Hypoxia-Inducible Factor 1-alpha …

Background: Hepatocellular carcinoma (HCC) originates from Epithelial cells, and epithelial
lineage plasticity has become a promising research direction for advancing HCC treatment …

Background Osteochondral defects pose an enormous challenge without satisfactory repair
strategy to date. In particular, the lateral integration of neo-cartilage into the surrounding …

Background Pregnant women and their fetuses are particularly susceptible to respiratory
pathogens. How they respond to SARS-CoV-2 infection is still under investigation. Methods …

Simple Summary Vascular Endothelial Growth Factor inhibitors (VEGFi), commonly
employed for diverse medical conditions such as advanced neoplasms and ocular diseases …

Microangiogenesis is an important prognostic factor in various cancers, including
hepatocellular carcinoma (HCC). The Vascular Endothelial Growth Factor (VEGF) has been …

Nowadays, the use of monoclonal antibodies to target angiogenic signalling pathways is
common, but, unfortunately, the clinical activity of these agents is limited. Thus, the …

Objective Dexmedetomidine (DEX), the most specific α 2-adrenergic receptor agonist widely
used for its sedative and analgesic properties, has been reported to upregulate HIF-1α …

ABSTRACT Hypoxia-inducible factor 1 (HIF-1) is a transcriptional regulator that mediates
cellular adaptive responses to hypoxia. Hypoxia-inducible factor 1α (HIF-1α) is involved in …