Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

The tremendous therapeutic potential of voltage-gated sodium channels (Navs) has been
the subject of many studies in the past and is of intense interest today. Nav1. 7 channels in …

The effective and safe treatment of pain is an unmet health-care need. Current medications
used for pain management are often only partially effective, carry dose-limiting adverse …

After nerve injury maladaptive changes can occur in injured sensory neurons and along the
entire nociceptive pathway within the CNS, which may lead to spontaneous pain or pain …

Neuropathic pain is triggered by lesions to the somatosensory nervous system that alter its
structure and function so that pain occurs spontaneously and responses to noxious and …

Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect
experienced by cancer patients receiving treatment with paclitaxel. The voltage-gated …

Epilepsy is a disease characterized by abnormal brain activity and a predisposition to
generate epileptic seizures, leading to neurobiological, cognitive, psychological, social, and …

Hyperalgesia and allodynia are frequent symptoms of disease and may be useful
adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in …

Spinal cord injury (SCI) is a devastating type of neurological trauma with limited therapeutic
opportunities. The pathophysiology of SCI involves primary and secondary mechanisms of …