Located between vessels of the choriocapillaris and light-sensitive outer segments of the
photoreceptors, the retinal pigment epithelium (RPE) closely interacts with photoreceptors in …

Age-related macular degeneration is the principal cause of registered legal blindness
among those aged over 65 in the United States, western Europe, Australia, and Japan …

Mutations in the gene BEST1 are causally associated with as many as five clinically distinct
retinal degenerative diseases, which are collectively referred to as the “bestrophinopathies” …

Best vitelliform macular dystrophy is a dominantly inherited, early onset, macular
degenerative disease that exhibits some histopathologic similarities to age-related macular …

Bestrophin-1 is an integral membrane protein, encoded by the BEST1 gene, which is
located in the basolateral membrane of the retinal pigment epithelium. The bestrophin-1 …

Stargardt-like macular dystrophy (STGD3, MIM 600110) and autosomal dominant macular
dystrophy (adMD) are inherited forms of macular degeneration characterized by decreased …

This article reviews the current state of knowledge about the bestrophins, a newly identified
family of proteins that can function both as Cl− channels and as regulators of voltage-gated …

Age-related macular degeneration (AMD) is the leading cause of vision loss and blindness
among older adults in the USA and throughout the developed world. Etiological research …

Absorption of light by rhodopsin or cone pigments in photoreceptors triggers
photoisomerization of their universal chromophore, 11-cis-retinal, to all-trans-retinal. This …

November 1997 issue of the American Journal of Ophthalmology, I proposed that age-
related macular degeneration is a vascular disorder, the hemodynamic sequela of …