Melanoma develops as a result of several genetic alterations, with UV radiation often acting
as a mutagenic risk factor. Deep knowledge of the molecular signaling pathways of different …

WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …

Once myocardium dies during a heart attack, it is replaced by scar tissue over the course of
several weeks. The size, location, composition, structure and mechanical properties of the …

Wnt proteins comprise a large family of highly conserved glycoproteins known for their role
in development, cell fate specification, tissue regeneration, and tissue homeostasis …

Fibroblasts are the predominant cell type in the cardiac interstitium. As the main matrix-
producing cells in the adult mammalian heart, fibroblasts maintain the integrity of the …

Chronic lung diseases represent a major public health problem with only limited therapeutic
options. An important unmet need is to identify compounds and drugs that target key …

Cardiac fibrosis, a common pathophysiologic process in most heart diseases, refers to an
excess of extracellular matrix (ECM) deposition by cardiac fibroblasts (CFs), which can lead …

Aims Myocardial fibrosis critically contributes to cardiac dysfunction in inflammatory dilated
cardiomyopathy (iDCM). Activation of transforming growth factor-β (TGF-β) signalling is a …

Abstract Purpose of Review Cardiovascular diseases are the leading cause of death
worldwide, largely due to the limited regenerative capacity of the adult human heart. In …