The polypeptide cytokine interleukin-1 (IL-1) affects nearly every tissue and organ system. IL-
1 is the prototype of the pro-inflammatory cytokines in that it induces the expression of a …

Publisher Summary This chapter reviews the role of cytokines in the pathogenesis of sepsis.
The various models for sepsis are also discussed, including the human models and animal …

Interleukin-1 (IL-1) interacts with cells through two types of binding molecules, IL-1 type I
receptor (IL-1R I) and IL-1R II. The function of IL-1R II is unknown. In studies using …

Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned
by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate …

cDNA clones corresponding to an Mr approximately 80,000 receptor (type I receptor) for
interleukin‐1 (IL‐1) have been isolated previously by mammalian expression. Here, we …

A monoclonal antibody (mAb) was isolated that blocked the binding and bioactivity of both
human and murine interleukin 1β (IL-1β) on murine IL-1 receptor-bearing cells. This mAb …

Two receptors for the proinflammatory cytokine interleukin 1 (IL-1) have been cloned and
characterized biochemically. While it has been well established that the type I (80-kDa) IL-1 …

Human monocytes cultured on adherent IgG produce a specific IL-1 inhibitor that functions
as a receptor antagonist (IL-1ra). This molecular has been purified, sequenced, cloned as a …

The interleukin-1 receptor antagonist (IL-1ra) is a protein capable of inhibiting receptor
binding and biological activities of IL-1 without inducing an IL-1-like response. Equilibrium …

We used gene targeting in embryonic stem cells to introduce an IL-lf3 null allele in mice. The
IL-lft-deficient mice develop normally and are apparently healthy and fertile. The IL-18 null …