An overview of brominated flame retardants in the environment

CA De Wit - Chemosphere, 2002 - Elsevier
The presence of brominated flame retardant (BFR) chemicals, and particularly
polybrominated diphenyl ethers (PBDEs), tetrabromobisphenol A (TBBPA) and …

Metabolism in the toxicokinetics and fate of brominated flame retardants—a review

H Hakk, RJ Letcher - Environment international, 2003 - Elsevier
Several classes of brominated flame retardants (BFRs), namely polybrominated biphenyls
(PBBs), polybrominated diphenyl ethers (PBDEs), tetrabromobisphenol A (TBBPA) …

[图书][B] Principles of protein X-ray crystallography

J Drenth - 2007 - books.google.com
X-ray crystallography is an established method for studying the structure of proteins and
other macromolecules. As the importance of proteins grows, researchers in many fields have …

Potent Competitive Interactions of Some Brominated Flame Retardants and Related Compounds with Human Transthyretin in Vitro

IATM Meerts, JJ Van Zanden, EAC Luijks… - Toxicological …, 2000 - academic.oup.com
Brominated flame retardants such as polybrominated diphenyl ethers (PBDEs),
pentabromophenol (PBP), and tetrabromobisphenol A (TBBPA) are produced in large …

Halogen bonding a novel interaction for rational drug design?

Y Lu, T Shi, Y Wang, H Yang, X Yan… - Journal of Medicinal …, 2009 - ACS Publications
Although recognized in small molecules for quite some time, the implications of halogen
bonding in biomolecular systems are only now coming to light. In this study, several systems …

Competitive binding of poly-and perfluorinated compounds to the thyroid hormone transport protein transthyretin

JM Weiss, PL Andersson, MH Lamoree… - Toxicological …, 2009 - academic.oup.com
Due to their unique surfactant properties, poly-and perfluorinated compounds (PFCs) have
been extensively used and can be found all over the environment. Concern about their …

Nonbonding interactions of organic halogens in biological systems: implications for drug discovery and biomolecular design

Y Lu, Y Wang, W Zhu - Physical Chemistry Chemical Physics, 2010 - pubs.rsc.org
Halogenation is an important approach in lead optimization for drug development and about
half of the molecules used in high-throughput screening are halogenated. However, there is …

Investigations into the nature of halogen bonding including symmetry adapted perturbation theory analyses

KE Riley, P Hobza - Journal of Chemical Theory and Computation, 2008 - ACS Publications
In recent years it has been recognized that, because of their unique properties, halogen
bonds have tremendous potential in the development of new pharmaceutical compounds …

Are brominated flame retardants endocrine disruptors?

J Legler, A Brouwer - Environment international, 2003 - Elsevier
Brominated flame retardants (BFRs) are a group of compounds that have received much
attention recently due to their similarity with “old” classes of organohalogenated compounds …

Disruption of the hypothalamic-pituitary-thyroid axis in zebrafish embryo–larvae following waterborne exposure to BDE-47, TBBPA and BPA

WK Chan, KM Chan - Aquatic toxicology, 2012 - Elsevier
We performed waterborne exposures of 2, 2′, 4, 4′-tetrabromodiphenyl ether (BDE-47),
tetrabromobisphenol A (TBBPA) or bisphenol A (BPA) on zebrafish (Danio rerio) embryo …