The cytochrome P450 monooxygenases (P450s) are thiolate heme proteins that can, often
under physiological conditions, catalyze many distinct oxidative transformations on a wide …

Nanodiscs have proven to be a versatile tool for the study all types of membrane proteins,
including receptors, transporters, enzymes and viral antigens. The self-assembled Nanodisc …

In contrast to the wide spectrum of cytochrome P450 monooxygenases, there are only 2
heme-based dioxygenases in humans: tryptophan dioxygenase (hTDO) and indoleamine 2 …

Acute myocardial infarction (AMI) is the leading cause of mortality worldwide. Myoglobin
protein was used as a biomarker for AMI because of its higher sensitivity compared with …

Copper (II)-hydroperoxo species are often detected as key intermediates in metalloenzymes
and biomimetic compounds containing copper. However, the only reactivity has previously …

Resonance Raman (RR) spectroscopy is used to help define active site structural responses
of nanodisc-incorporated CYP3A4 to the binding of three substrates: bromocriptine (BC) …

The heme-based chlorite dismutases catalyze the unimolecular decomposition of chlorite
(ClO2–) to yield Cl–and O2. The work presented here shows that chlorite dismutase from …

The first step in the enzymatic cycle of mammalian peroxidases, including lactoperoxidase
(LPO), is binding of hydrogen peroxide to the ferric resting state to form a ferric-hydroperoxo …

The complex multistep mechanism of oxygen activation in P450 is reviewed as a sequence
of the following reactions: Substrate binding, reduction of the heme iron from ferric to the …

The activity of many biopharmaceutical polymers is dependent on conformation, and the
next several years will see increased interest in the conformational analysis of these …