[HTML][HTML] Advances in cancer therapy: A comprehensive review of CDK and EGFR inhibitors
M Hawash - Cells, 2024 - mdpi.com
Protein kinases have essential responsibilities in controlling several cellular processes, and
their abnormal regulation is strongly related to the development of cancer. The …
their abnormal regulation is strongly related to the development of cancer. The …
Rationale, in silico docking, ADMET profile, design, synthesis and cytotoxicity evaluations of phthalazine derivatives as VEGFR-2 inhibitors and apoptosis inducers
HH Bayoumi, MK Ibrahim, MA Dahab, F Khedr… - RSC …, 2024 - pubs.rsc.org
New phthalazine derivatives as vascular endothelial growth factor receptor-2 (VEGFR-2)
inhibitors were synthesized joined to different spacers including pyrazole, α, β-unsaturated …
inhibitors were synthesized joined to different spacers including pyrazole, α, β-unsaturated …
Exploration of the VEGFR-2 inhibition activity of phthalazine derivatives: design, synthesis, cytotoxicity, ADMET, molecular docking and dynamic simulation
HH Bayoumi, MK Ibrahim, MA Dahab, F Khedr… - RSC …, 2024 - pubs.rsc.org
Novel phthalazine derivatives were designed, synthesized and evaluated against Hep G2
and MCF-7 as VEGFR-2 inhibitors. In particular, compounds 2g and 4a were found to be the …
and MCF-7 as VEGFR-2 inhibitors. In particular, compounds 2g and 4a were found to be the …
Exploration of cytotoxicity of iodoquinazoline derivatives as inhibitors of both VEGFR‐2 and EGFRT790M: Molecular docking, ADMET, design, and syntheses
M Alsulaimany, SSA El‐Hddad, ZSM Akrim… - Archiv der …, 2024 - Wiley Online Library
Novel inhibitors of epidermal growth factor receptor (EGFR) T790M/vascular endothelial
growth factor receptor‐2 (VEGFR‐2) were synthesized based on the iodoquinazoline …
growth factor receptor‐2 (VEGFR‐2) were synthesized based on the iodoquinazoline …
Anticancer evaluations of iodoquinazoline substituted with allyl and/or benzyl as dual inhibitors of EGFR WT and EGFR T790M: design, synthesis, ADMET and …
Fifteen new iodoquinazoline derivatives, 5a, b to 18, are reported in this study and their
anticancer evaluation as dual inhibitors of EGFRWT and EGFRT790M. The new derivatives …
anticancer evaluation as dual inhibitors of EGFRWT and EGFRT790M. The new derivatives …
Phthalazine Derivatives as VEGFR‐2 Inhibitors: Docking, ADMET, Synthesis, Design, Anticancer Evaluations, and Apoptosis Inducers
HH Bayoumi, MK Ibrahim, MA Dahab… - Drug Development …, 2025 - Wiley Online Library
New phthalazine‐derived inhibitors for VEGFR‐2 were synthesized for anticancer
evaluations. Also, docking studies were performed to explore the suggested binding …
evaluations. Also, docking studies were performed to explore the suggested binding …
New benzimidazole‐oxadiazole derivatives as potent VEGFR‐2 inhibitors: Synthesis, anticancer evaluation, and docking study
We report herein, the design and synthesis of benzimidazole‐oxadiazole derivatives as new
inhibitors for vascular endothelial growth factor receptor‐2 (VEGFR‐2). The designed …
inhibitors for vascular endothelial growth factor receptor‐2 (VEGFR‐2). The designed …