Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the
extracellular matrix. In this Review, we draw on experiments performed in mammalian cells …

Cell adhesion to the extracellular matrix (ECM), mediated by transmembrane receptors of
the integrin family, is exquisitely sensitive to biochemical, structural, and mechanical …

Talin, a force-bearing cytoplasmic adapter essential for integrin-mediated cell adhesion,
links the actin cytoskeleton to integrin-based cell–extracellular matrix adhesions at the …

The force-dependent interaction between talin and vinculin plays a crucial role in the
initiation and growth of focal adhesions. Here we use magnetic tweezers to characterise the …

The integrin family of transmembrane adhesion receptors is essential for sensing and
adhering to the extracellular environment. Integrins are heterodimers composed of non …

Focal adhesions (FAs) are protein machineries essential for cell adhesion, migration, and
differentiation. Talin is an integrin-activating and tension-sensing FA component directly …

Talins are cytoplasmic adapter proteins essential for integrin‐mediated cell adhesion to the
extracellular matrix. Talins control the activation state of integrins, link integrins to …

Cell-extracellular matrix interactions have been studied extensively using cells cultured in
vitro. These studies indicate that focal adhesion (FA)-based cell-extracellular matrix …

Epithelial apical-basal polarity drives assembly and function of most animal tissues. Polarity
initiation requires cell-cell adherens junction assembly at the apical-basolateral boundary …

Collective cell movements contribute to tissue development and repair and spread
metastatic disease. In epithelia, cohesive cell movements require reorganization of …