Abstract The phosphatidylinositol 3-kinase (PI3K) signalling pathway regulates cell survival,
proliferation, migration, metabolism and other vital cellular life processes. In addition …

Fatty acid metabolism has been deciphered to augment tumorigenesis and disease
progression in addition to therapy resistance via strengthened lipid synthesis, storage, and …

Abstract The PI3K/Akt/mTOR pathway plays a role in various oncogenic processes in breast
cancer and key pathway aberrations have been identified which drive the different molecular …

PI3K inhibitors with differential selectivity to distinct PI3K isoforms have been tested
extensively in clinical trials, largely to target tumor epithelial cells. PI3K signaling also …

Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease that exhibits constitutive
activation of phosphoinositide 3-kinase (PI3K) driven by chronic B-cell receptor signaling or …

Purpose: Statins are associated with lower risk of aggressive prostate cancer, but lethal
prostate cancer is understudied and contributing mechanisms are unclear. We prospectively …

Simple Summary The PI3K/AKT pathway is one of the most important signaling nodes in
cancer. While class I PI3K roles in cancer are well known, class II and III functions in …

The γ isoform of Class I PI3Ks (PI3Kγ) is primarily found in leukocytes and is essential for the
function of myeloid cells, as it regulates the migration, differentiation, and activation of …

Introduction: Treatment options for biliary tract cancer (BTC) are very limited. It is necessary
to investigate actionable genes and candidate drugs using a sophisticated knowledgebase …

Introduction Copper metabolism encompasses all cellular metabolic processes involving
copper ions and plays a significant role in the pathogenesis of diseases, including cancer …