[HTML][HTML] Procalcitonin as a biomarker of infectious diseases
H Lee - The Korean journal of internal medicine, 2013 - ncbi.nlm.nih.gov
Traditional biomarkers, including C-reactive protein, leukocytes, erythrocyte sedimentation
rate, and clinical signs and symptoms, are not sufficiently sensitive or specific enough to …
rate, and clinical signs and symptoms, are not sufficiently sensitive or specific enough to …
Sepsis: Something old, something new, and a systems view
Sepsis is a clinical syndrome characterized by a multisystem response to a microbial
pathogenic insult consisting of a mosaic of interconnected biochemical, cellular, and organ …
pathogenic insult consisting of a mosaic of interconnected biochemical, cellular, and organ …
The acute inflammatory response in trauma/hemorrhage and traumatic brain injury: current state and emerging prospects
Traumatic injury/hemorrhagic shock (T/HS) elicits an acute inflammatory response that may
result in death. Inflammation describes a coordinated series of molecular, cellular, tissue …
result in death. Inflammation describes a coordinated series of molecular, cellular, tissue …
Sepsis gene expression profiling: murine splenic compared with hepatic responses determined by using complementary DNA microarrays
Objective DNA microarrays allow genome-wide assessment of changes in relative
messenger RNA abundance and thus can be used to monitor changes in gene expression …
messenger RNA abundance and thus can be used to monitor changes in gene expression …
Injury research in the genomic era
JP Cobb, GE O'Keefe - The Lancet, 2004 - thelancet.com
With the development of trauma systems, improved resuscitation, and organ system support,
survival after severe injury is common, but is often complicated by nosocomial infection and …
survival after severe injury is common, but is often complicated by nosocomial infection and …
In silico modeling: methods and applications to trauma and sepsis
Y Vodovotz, TR Billiar - Critical care medicine, 2013 - journals.lww.com
Objectives: To familiarize clinicians with advances in computational disease modeling
applied to trauma and sepsis. Data Sources: PubMed search and review of relevant medical …
applied to trauma and sepsis. Data Sources: PubMed search and review of relevant medical …
Translational systems biology: introduction of an engineering approach to the pathophysiology of the burn patient
The pathophysiology of the burn patient manifests the full spectrum of the complexity of the
inflammatory response. In the acute phase, inflammation may have negative effects via …
inflammatory response. In the acute phase, inflammation may have negative effects via …
Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia
M Weber, S Lambeck, N Ding, S Henken… - The FASEB …, 2012 - Wiley Online Library
Community‐acquired pneumonia presents a spectrum of clinical phenotypes, from lobar
pneumonia to septic shock, while mechanisms underlying progression are incompletely …
pneumonia to septic shock, while mechanisms underlying progression are incompletely …
APOE polymorphism is associated with risk of severe sepsis in surgical patients
EW Moretti, RW Morris, M Podgoreanu… - Critical care …, 2005 - journals.lww.com
Objective: To test for an association between apolipoprotein E (APOE) genotypes and the
occurrence of severe sepsis in an elective surgical cohort. Design: Prospective …
occurrence of severe sepsis in an elective surgical cohort. Design: Prospective …
From data patterns to mechanistic models in acute critical illness
The complexity of the physiologic and inflammatory response in acute critical illness has
stymied the accurate diagnosis and development of therapies. The Society for Complex …
stymied the accurate diagnosis and development of therapies. The Society for Complex …