Drug lag, recently discussed extensively in Japan, can be divided into two phases: clinical
development time and application review time. The former factor is still an important problem …

Importance The antiepileptic drug phenytoin can cause cutaneous adverse reactions,
ranging from maculopapular exanthema to severe cutaneous adverse reactions, which …

Introduction: Notably differences in CYP2C9 allele frequencies among worldwide
populations have been reported, with an interesting low frequency of the CYP2C9* 2 allele …

Genetic polymorphisms of CYP2C9 significantly influence the pharmacokinetics and
pharmacodynamics of some drugs, which might result in adverse drug effects and …

Warfarin, a widely prescribed oral anticoagulant, is used for the prevention of
thromboembolism. Polymorphisms in CYP2C9 and VKORC1 have been shown to be …

Warfarin is a commonly used oral anticoagulant with a narrow therapeutic range and large
interindividual variability in daily dose. Compared with Caucasians, Chinese are known to …

Abstract Background CYP2C9 and VKORC1 are two major genetic factors associated with
inter-individual variability in warfarin dose. Additionally, genes in the warfarin metabolism …

Abstract Within the Asian populations, Indian patients had been reported to require higher
warfarin dose compared with the Chinese and Malay patients, and this could not entirely be …

Abstract CYP2C9 metabolizes approximately 20% of clinically used drugs, including the
narrow therapeutic window drugs warfarin and phenytoin. More than 16,000 variants have …

Compared to Europe, data on genetic variation in genes transcribing drug metabolizing
enzymes among Asian is limited due to ethnic diversity. Here we compare frequencies for …