Diacylglycerol (DAG) is a lipid second messenger that is generated in response to
extracellular stimuli and channels intracellular signals that affect mammalian cell …

The characterization of the receptors negatively modulating lymphocyte function is rapidly
advancing, driven by success in tumor immunotherapy. As a result, the number of immune …

Diacylglycerol kinases (DGK) are a family of enzymes that catalyze the transformation of
diacylglycerol into phosphatidic acid. In T lymphocytes, DGKα and ζ limit the activation of the …

The diacylglycerol kinases (DGKs) attenuate diacylglycerol (DAG)–mediated signals by
catalyzing the conversion of DAG to phosphatidic acid. In T lymphocytes, the antigen …

Background Antibody-based therapies blocking the programmed cell death-1/ligand-1 (PD-
1/PD-L1) axis have provided unprecedent clinical success in cancer treatment. Acquired …

It is well established that extracellular proteins that negatively regulate T cell function, such
as Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4) and Programmed Cell Death …

Diacylglycerol kinase (DGK) α converts diacylglycerol to phosphatidic acid. This lipid kinase
sustains survival, migration and invasion of tumor cells, with no effect over untransformed …

The diacylglycerol kinase family, which can attenuate diacylglycerol signaling and activate
phosphatidic acid signaling, regulates various signaling transductions in the mammalian …

The engagement of the T cell receptor (TCR) induces the generation of diacylglycerol
(DAG), an important second messenger activating both the Ras/Erk and PKCθ/NFκB …

Diacylglycerol kinase (DGK)‐mediated consumption of the diacylglycerol (DAG) generated
in response to antigen recognition is an important mechanism to limit T‐cell function …