Within the canonical repertoire of the amino acid involved in protein biogenesis, proline
plays a unique role as an amino acid presenting a modified backbone rather than a side …

Electron deficient, bivalent sulfur atoms have two areas of positive electrostatic potential, a
consequence of the low-lying σ* orbitals of the C–S bond that are available for interaction …

Gramicidin S (GS), one of the oldest commercially used peptide antibiotics, is known for its
robust antibacterial activity against both Gram-positive and Gram-negative bacterial strains …

The rise of antibiotic resistant bacteria requires unconventional strategies toward efficient
chemotherapeutic agents, preferably with alternative mechanisms of action. The bacterial …

Gramicidin S is a naturally occurring antimicrobial cyclic peptide. Herein, we present a
series of cyclic peptides based on gramicidin S that contain an azobenzene photoswitch to …

Naturally occurring cyclic antimicrobial peptides (AMPs) such as tyrocidine A (Tyrc A) and
gramicidin S (GS) are appealing targets for the development of novel antibiotics. However …

Antimicrobial peptides (AMPs) are amphipathic molecules displaying broad-spectrum
bactericidal activity, providing opportunities to develop a new generation of antibiotics …

We report on the structure of Gramicidin S (GS) in a model membrane mimetic environment
represented by the amphipathic solvent 1-octanol using one-dimensional (1D) and two …

A practical multigram metal free synthesis of isoxazole-containing building blocks from
commercially available amino acids was elaborated. The key reaction was a regioselective …

Despite their concomitant emergence in the 1990s, γ‐peptide foldamers have not developed
as fast as β‐peptide foldamers and to date, only a few γ‐oligomer structures have been …