A systematic review of the global intervention for SARS-CoV-2 combating: from drugs repurposing to molnupiravir approval
NA Ashour, A Abo Elmaaty, AA Sarhan… - Drug design …, 2023 - Taylor & Francis
The rising outbreak of SARS-CoV-2 continues to unfold all over the world. The development
of novel effective antiviral drugs to fight against SARS-CoV-2 is a time cost. As a result, some …
of novel effective antiviral drugs to fight against SARS-CoV-2 is a time cost. As a result, some …
Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti …
Pirfenidone (PFD) is a non-peptide synthetic chemical that inhibits the production of
transforming growth factor-beta 1 (TGF-β1), tumor necrosis factor-alpha (TNF-α), platelet …
transforming growth factor-beta 1 (TGF-β1), tumor necrosis factor-alpha (TNF-α), platelet …
Design, synthesis, and biological evaluation of thienopyrimidine derivatives as multifunctional agents against Alzheimer's disease
KI Eissa, MM Kamel, LW Mohamed… - Drug Development …, 2023 - Wiley Online Library
A series of 12 S‐substituted tetrahydrobenzothienopyrimidines were designed and
synthesized based on the donepezil scaffold. All the newly synthesized compounds were …
synthesized based on the donepezil scaffold. All the newly synthesized compounds were …
Design, synthesis, and SAR studies of novel 4-methoxyphenyl pyrazole and pyrimidine derivatives as potential dual tyrosine kinase inhibitors targeting both EGFR …
Guided by the pharmacophoric features of both EGFR and VEGFR-2 antagonists, two novel
series of 4-methoxyphenyl pyrazole and pyrimidine derivatives [(4a-c) and (5a-c, 6, 7a-c, 8 …
series of 4-methoxyphenyl pyrazole and pyrimidine derivatives [(4a-c) and (5a-c, 6, 7a-c, 8 …
Ligand-based design on the dog-bone-shaped BIBR1532 pharmacophoric features and synthesis of novel analogues as promising telomerase inhibitors with in vitro …
Telomerase is an outstanding biological target for cancer treatment. BIBR1532 is a non-
nucleoside selective telomerase inhibitor; however, it experiences ineligible …
nucleoside selective telomerase inhibitor; however, it experiences ineligible …
Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and …
Although the great effectiveness of doxorubicin (Dox) in the treatment of many types of
tumors, it showed limited effectiveness against the head and neck squamous cell carcinoma …
tumors, it showed limited effectiveness against the head and neck squamous cell carcinoma …
Synthesis of new organoselenium-based succinanilic and maleanilic derivatives and in silico studies as possible SARS-CoV-2 main protease inhibitors
Herein we report the synthesis of organic selenide-based maleanilic and succinanilic acids
in good yields (up to 95%). Their structural identities were elucidated by spectroscopic …
in good yields (up to 95%). Their structural identities were elucidated by spectroscopic …
Synthesis, structural characterization, DFT calculations, molecular docking, and molecular dynamics simulations of a novel ferrocene derivative to unravel its potential …
MM Hammoud, M Khattab, M Abdel-Motaal… - Journal of …, 2023 - Taylor & Francis
In this article, we describe a set of subsequent five-steps chemical reactions to synthesize a
ferrocene derivative named 1-(5-(diphenylphosphaneyl) cyclopenta-1, 3-dien-1-yl) ethyl) …
ferrocene derivative named 1-(5-(diphenylphosphaneyl) cyclopenta-1, 3-dien-1-yl) ethyl) …
Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: in vitro, in vivo, molecular docking, molecular dynamics, and …
Apparently, tubulin inhibitors binding to the colchicine-binding site (CBS) currently have
outstanding attention for cancer treatment. So, a series of benzo [b] azonin-2-one derivatives …
outstanding attention for cancer treatment. So, a series of benzo [b] azonin-2-one derivatives …
Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR Studies
A Abo Elmaaty, WM Eldehna, M Khattab… - International Journal of …, 2022 - mdpi.com
In this article, 34 anticoagulant drugs were screened in silico against the main protease
(Mpro) of SARS-CoV-2 using molecular docking tools. Idraparinux, fondaparinux …
(Mpro) of SARS-CoV-2 using molecular docking tools. Idraparinux, fondaparinux …