Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Diabetic kidney disease (DKD) remains one of the leading causes of reduced lifespan in
diabetes. The quest for both prognostic and surrogate endpoint biomarkers for advanced …

Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth
factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very …

Objective: To validate new mitochondrial myopathy serum biomarkers for diagnostic use.
Methods: We analyzed serum FGF21 (S-FGF21) and GDF15 from patients with (1) …

High concentrations of extracellular phosphate are toxic to cells. Impaired urinary phosphate
excretion increases serum phosphate level and induces a premature-ageing phenotype …

The circulating FGFs are a new group of proteins believed to function as classic hormones.
With emphasis on human metabolism, we critically review current data, and propose that …

Here we evaluated the performance of a large set of serum biomarkers for the prediction of
rapid progression of chronic kidney disease (CKD) in patients with type 2 diabetes. We used …

Despite the emerging importance of fibroblast growth factor 21 (FGF21) as a metabolic
hormone regulating energy balance, its direct effects on renal function remain unexplored …

Abstract Fibroblast growth factor 21 (FGF21), a 181 amino acid circulating protein, is a
member of the FGF superfamily, with relevant metabolic actions. It acts through the …

Background Fibroblast growth factor 21 (FGF21) is a hepatic hormone involved in the
regulation of lipid and carbohydrate metabolism. This study aims to test the hypothesis that …