Hypoxia is a non-physiological level of oxygen tension, a phenomenon common in a
majority of malignant tumors. Tumor-hypoxia leads to advanced but dysfunctional …

Tumour hypoxia is increasingly recognized as a major deleterious factor in cancer therapies,
as it compromises treatment and drives malignant progression. This review seeks to clarify …

The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …

Cancer cells face various metabolic challenges during tumor progression, including growth
in the nutrient-altered and oxygen-deficient microenvironment of the primary site …

Introduction‐Imaging of hypoxic areas‐Hypoxia markers‐Positron emission tomography
(PET)‐Near‐infrared spectroscopy (NIRS)‐Magnetic resonance spectroscopy (MRS) …

Tumor hypoxia is a well-established biological phenomenon that affects the curability of
solid tumors, regardless of treatment modality. Especially for head and neck cancer patients …

Chemodynamic therapy (CDT) by introducing the Fenton‐/Fenton‐like reaction in an acidic
and H2O2 environment for toxic hydroxyl radical (• OH) generation, is a newly developed …

Hypoxia, a characteristic feature of locally advanced solid tumors, has emerged as a pivotal
factor of the tumor (patho-) physiome since it can promote tumor progression and resistance …

The tumor microenvironment includes a complicated network of physiological gradients
contributing to plasticity of tumor cells and heterogeneity of tumor tissue. Hypoxia is a key …

Exosomes are defined as submicron (30–150 nm), lipid bilayer-enclosed extracellular
vesicles (EVs), specifically generated by the late endosomal compartment through fusion of …