Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

The purpose of this review is to highlight the recent mechanistic developments elucidating
the role of matrix metalloproteinases (MMPs) in tumour invasion and metastasis. The ability …

Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The
expression and function of the membrane-type matrix metalloproteinase MMP14 is closely …

The epithelial to mesenchymal transition (EMT) program is a crucial component in the
processes of morphogenesis and embryonic development. The transition of epithelial to …

Mechanical rigidity in the tumor microenvironment is associated with a high risk of tumor
formation and aggressiveness. Adhesion-based signaling driven by a rigid …

Many solid cancers have an expanded CD44+/hi/CD24−/low cancer stem cell (CSC)
population, which are relatively chemoresistant and drive recurrence and metastasis …

One of the strategies used by cells to degrade and remodel the extracellular matrix (ECM) is
based on invadosomes, actin-based force-producing cell–ECM contacts that function in …

Efficient tumor cell invasion into the surrounding desmoplastic stroma is a hallmark of cancer
progression and involves the navigation through available small tissue spaces existent …

ROCK activity increases due to ECM rigidity in the tumor microenvironment and promotes a
malignant phenotype via actomyosin contractility. Invasive migration is facilitated by actin …

Sprouting angiogenesis, the formation of new vessels from preexisting vasculature, is an
essential process in the regeneration of new tissues as well as in the development of some …