Glycogen, the primary storage form of glucose, is a rapid and accessible form of energy that
can be supplied to tissues on demand. Each glycogen granule, or" glycosome," is …

The brain contains a fairly low amount of glycogen, mostly located in astrocytes, a fact that
has prompted the suggestion that glycogen does not have a significant physiological role in …

Matrix assisted laser desorption/ionization imaging has greatly improved our understanding
of spatial biology, however a robust bioinformatic pipeline for data analysis is lacking. Here …

Glycosylation defects are a hallmark of many nervous system diseases. However, the
molecular and metabolic basis for this pathology is not fully understood. In this study, we …

Nuclear glycogen was first documented in the early 1940s, but its role in cellular physiology
remained elusive. In this study, we utilized pure nuclei preparations and stable isotope …

Autophagy is an essential cellular process involving degradation of superfluous or defective
macromolecules and organelles as a form of homeostatic recycling. Initially proposed to be …

Lafora disease (LD) is a fatal childhood epilepsy caused by recessive mutations in either the
EPM2A or EPM2B gene. A hallmark of LD is the intracellular accumulation of insoluble …

The overaccumulation of glycogen appears as a hallmark in various glycogen storage
diseases (GSDs), including Pompe, Cori, Andersen, and Lafora disease. Accumulating …

Polysaccharides are foreseen as serious candidates for the future generation of polymers,
as they are biosourced and biodegradable materials. Their functionalisation is an attractive …

The hallmark of Lafora disease, a fatal neurodegenerative disorder, is the accumulation of
intracellular glycogen aggregates called Lafora bodies. Until recently, it was widely believed …